Thursday, May 18, 2017

Intellia moves closer to clinic with CRISPR tech

Intellia Therapeutics has taken another step toward human trials of its gene editing technology after reporting new data in animal models.

The CRISPR specialist says it has been able to show for the first time that it is able to not only achieve long-term suppression of a gene using its gene-editing CRISPR/Cas9 drug, in this case the sequence coding for serum transthyretin (TTR) protein, but also demonstrate a dose-dependent reduction in the activity of the target gene in a second animal species.

New data from studies in mice show that a previously reported 97% reduction in TTR—driven by 70% gene editing efficiency working in mouse livers—lasts for up to six months from a single dose. Meanwhile, a study in rats showed a similar dose-dependent reduction in the TTR gene, and crucially evidence of comparable activity in a second species as Intellia builds the case to move to the clinic.

Biotech pioneer and former Genzyme CEO Henri Termeer dies

The biotech industry is mourning the loss of one of the sector's founding fathers after the death of Genzyme founder Henri Termeer at the age of 71.

According to the Boston Globe, Termeer died after collapsing at his home in Marblehead, Massachusetts, on Friday night.

Termeer was at the helm of Genzyme for nearly 30 years, joining the company in 1983 and rising quickly to the role of CEO before it was acquired by Sanofi in 2011 for more than $20 billion. He is credited with not only transforming the small company into one of the world's leading biotech companies but also playing a leading role in working out how to develop a business model that opened up the market for rare and orphan disease therapies—to the benefit of patients and shareholders alike.


Biotech pioneer and former Genzyme CEO Henri Termeer dies

Thursday, May 11, 2017

Prof. Dr. M. Amjad Hossain: Make your Appointment in Hotline

Prof. Dr. M. Amjad Hossain
MBBS, MS (Ortho)
Arthoplasty and trauma surgeon
President Bangladesh Orthopaedic Society
Former Professor & Head Orthopaedic Surgeon
Dhaka Medical College & Hospital
Chief Consultant
Orthopaedic Surgery Dept
Lab Aid Arthroplasty Center
Labaid Hospital Ltd,
Dhanmondi, Dhaka-1205.
Contact number: + 8801711530611

Best Practice to make your Appointment for Prof. Dr. M Amjad Hossain. Dr. Amjad hossain is the leading leader & expert Ortho Surgery across the country. 

It is little bit difficult to get appointment to him. Currently, HOTLINE is managing all the appointment behalf of LABAID HOSPITAL LTD. 

How make Appointment

# Dial Hotline 10606 the day before you wish to make Appointment

# Start Calling from couple of Mobile phone from 10:55 am.

# Hotline number is busy always. And it may take only 2 mint for Hotline to record appointment for Dr. Amjad Hossain. Because hotline has many desk and the call automatically distribute to several Desk and many of customers service agent offer appointment at a time. 

# So if you hear the voice that number is busy now. Do not cut the line. Stay connected in the line continue. When the call finished then re-dial immediately again. 

# If you try from a single number than it will be rarely possible to make your appointment. So try from different Mobile at a same time together but not from separate place. If you try from separate places, the same appointment can be booked multiple times which will interfere the HOTLINE Database. Accidentally, if you make multiple appointment for a single patient, it is your responsibility to re-call in HOTLINE and inform them that you did.


Read More About Prof. Dr. M. Amjad Hossain



Wednesday, May 10, 2017

Orthopedic Surgeon: A Bizarre Success Story behind Prof. Dr. M Amjad Hossain


Prof. Dr. M Amjad Hossain was born in Shukdebpur, Dinajpur, Bangladesh in 1953. He was an young freedom fighter. Its sorrow that to express he was injured in the war of Liberation in 1971 (between Bangladesh & Pakistan) when he was only 19 years old. He was shot on his Femur and was cured by Dr. R. J. Garst. And from that moment, he vowed that he too would dedicate his life to saving others and influenced himself to be an Orthopedic Physician. 

Family

A proud Son of Late Abdul Baki (Father) & Al-haj Amena Khatoon (Mother)

Educational and Social Background

  1. Chirirbandar Pilot High School, Dinajpur, Bangladesh (S.S.C-1968)
  2. Dinajpur Government College, Dinajpur, Bangladesh (H.S.C-1970)
  3. Dhaka Medical College, Dhaka, Bangladesh (M.B.B.S-1972 to 1978)
  4. Dhaka Medical College, Dhaka, Bangladesh (M.S on Ortho 1983 to 1986)

Foreign Training

  • Participated in the ILLIZAROV "HANDS ON TRAINING WORKSHOP" for limb lengthening procedure at Nil Ratan Sarkar Medical College, Calcutta, India. (Nov 1992)
  • 'AO' (Association for Osteosynthesis), Basic course at Singapore (April 1994).
  • As a Travelling Fellow offered by DR. R.J GARST to different institutes of USA (SEP-OCT 1994).
  • Advanced 'AO Fellowship' Course in Institute of Orthopaedics & Traumatolgy, Catherine Hospital, Stuttgart, Germany (June-July 1995).
  • Fellowship Training in Re-Constructive Hand & Micro Surgery offered by WOC (World Orthopedic Concern) in Institute of Research and Rehabilitation for HAND (IRRH) STANLY Medical College, Madras, India (Dec-Feb:1996-1997).
  • Visiting Fellowship in Sushrut Hospital, Research Center and Post Graduate Institute of Orthopedics, Nagpur, India (Dec 1998).
  • Advanced Training Program on Replacement Surgery for Hip & Knee, Bombay Hospital & Institute of Research, Bombay, India (November 2000).
  • Ambassadorial Fellowship in Australia offered by Asia Pacific Orthopedic Association (APOA) (April 2001).
  • Next proposed Fellowship Training in Department of Orthopedic Surgery, Beth Isreal Medical Center for Knee and Shoulder Replacement and Sports Medicine, New York, U.S.A in (2002).


Service History

Service History
29/09/1978 to 16/11/1979
:
In Service Trainee, Dhaka Medical College  Hospital , Dhaka, Bangladesh
17/11/1979 to 25/06/1981
:
Medical Office ( MCH-FP ) , Parbatipur Thana Health Complex, Dinajpur
30/06/1981 to 30/06/1982
:
Medical Officer, National Institute of Traumatology and Orthopedic Rehabilitation ( Former Rehabilitation Institute & Hospital for the Disabled ) , Dhaka
01/07/1982 to 01/07/1983
:
Clinical Assistant, General Surgery, Institute for Post Graduate Medicine & Research ( IPGMR ) , Dhaka
01/07/1983 to 15/07/1986
:
M.S Orthopaedic Student.  National Institute of Traumatology and Orthopedic Rehabilitation ( Former Rehabilitation Institute & Hospital for the Disabled ) ,  Dhaka
15/07/1986 to 25/06/1989
:
Clinical Assistant ,  Orthopedic Surgery, National Institute of Traumatology and Orthopedic Rehabilitation ( Former Rehabilitation Institute & Hospital for the Disabled ) , Dhaka
25/06/1989 to 24/04/1991
:
Junior Consultant , Department of Casualty
Dhaka Medical College Hospital, Dhaka
25/04/1991 to 28/02/1994
:
Assistant Professor  of Orthopaedic Surgery  , RIHD , Dhaka
01/03/1994 to 21/11/1995
:
Associate Professor ( CC ) , Orthopedic Surgery,
National Institute of Traumatology and
Orthopedic Rehabilitation (former Rehabilitation Institute & Hospital for the Disabled), Dhaka
22/11/1995 to 25/06/1996
:
Associate Professor, Orthopedic Surgery,
MAG Osmani Medical College, Sylhet
04/07/1996 to 09/11/2001
:
Associate Professor,  Orthopedic Surgery
National Institute of Traumatology and Orthopedic Rehabilitation (former Rehabilitation , Institute & Hospital Dhaka
                                                           
21/05/2001 to 09/05/2004                                                 : Professor and Head of the Department of

 

:
Professor (CC). National Institute of Traumatology & Orthopedic Rehabilitation
Dhaka Medical College. Dhaka, Bangladesh
10/05/2004 to 24/03/2007
:
Professor & Head. Orthopedic Surgery
Dhaka Medical College. Dhaka, Bangladesh
27/03/2007 to  30/09/2007
:
Professor & Head. Orthopedic Surgery
Mymenshingh Medical College. Dhaka, Bangladesh
01/10/2007 to till date
:
Chief Consultant  & Head
Orthopedic Surgery
Lab Aid Hospital, Dhanmondi, Dhaka.

Conference Attended

  • 38th Indian Orthopedic Association Conference, Bhupal, India, (November 1993).
  • Continued Medical Education (CME) of Indian Ortho, Association Bhupal, India (November 1993).
  • XII Continued Orthopedic Education ourse (C.O.E.) on "Injuries Diseases & deformities of the foot & ankle, Calcutta, India (September 1994).
  • International symposium on Orthopedic oncology Apollo Cancer Hospital, Madras, India, (January 1997).
  • 49th Hand Surgery Conference, Cincinnati, Ohio, USA, (October 1994).
  • The Second Congress of the European Federation of National Associations for Orthopedic & Traumatology, Munich- (July 4-7, 1995).
  • ROC 8th Kolkata, India, (January 2010).
  • Visited Mumbai on 20th to 25th February 2011 as an observer for Artroplasty in Lilavati, Railway Hospital, Ambai Hospital

National & International Membership

  1. President of Bangladesh Orthopedic Society.
  2. Life Member of Society for Surgeons of Bangladesh.
  3. Life Member of West Bengal Orthopedic Association.
  4. Life Member of Indian Orthopedic Association.
  5. Life Member of Trauma Society India.
  6. Life Member of SAARC Orthopedic Association.
  7. Life Member of Aisa Pacific Orthopedic Association.
  8. Member of Indian Arthoplasty Association.
  9. "AO" Alumni Association.
  10. Member of AAOS (American Academic of Orthopedic Surgeons)
  11. Member of SICOT.
  12. Member of BJD (NAN)
  13. Secretary General of Bangladesh Arthoplasty Association.

Social Works

  1. Founder of Amana Baki Residential Model School, Chirrirbandar, Dinajpur-2001.
  2. Founder & President- Amena Baki Foundation (A Social Welfare Organization)- 2000
  3. Fonder Member of Shahid Shajahan School, Sukhdevpur, Chirrirbandar, Dinajpur- 1973.
  4. Founder Member of Sukhdevpur Hazi Kalimuddin Madrasha- 2001
  5. Health Adviser (Honorary), Bangladesh Freedom Fighter Welfare Trust sincep- 1981
  6. Elected Member of Secretarial Board, Bangladesh Muktijoddah Sangsad, Central Command Council- 2000
  7. Vice President Elected at Bangladesh Orthopedic Society- 2001, Fonder of Orthopedic Care & Research Center (OCRC), Humayun Road, Mohammadpur, Dhaka 

Freedom Fight

  1. Actively took part in the war of Liberation in 1971 (7th Sector) & had been treated in different Indian Military Hospital as an war injured Freedom Fighter.
  2. Served for the treatment of war injured & Disabled freedom fighter as honorary adviser to Bangladesh Freedom Fighter welfare Trust.
  3. EC member Central Command Council, Bangladesh Muktijodha Sangshad 1999.
  4. Member, Secotor commander's forum.

#Short story of Prof. Dr. M Amjad Hossain told himself about the moment of Freedom Fight#

In 1971, I was a young man who has just passed his intermediate exams. My father wanted me to join the army. During the tensed days of March, I was at the cantonment for my ISSB exams. The hatred of the Pakistani soldiers and their commanders towards the Bengalis and Sheikh Mujib was quite clear there. The oppression that we were under the last two decades, how the Pakistanis treated us like vermin, how they exploited us financially and politically- all these created a spark in me. After the military crackdown, it went ablaze.

After the slaughter of 25th march, my family searched for a safe haven. A large number of non-bengali Biharis lived in an around my home Chirirbandor Dinajpur, so it wasn’t safe there. The women moved to remote villages. After geting the full information for the Pakistani Army they would not allow us to live with dignity rather they will crash the Bengalis. So my father took 25 young man and cross the border for west Dinajpur. It was 3rd week of April when the exile Bangladesh Govt. has formed under the Leadership of Taj Uddin Ahmed and Syed Nazrul Islam and the guerilla war started. We reached kamarpara camp where I was trained in guerilla warfare under Prof. Abu Sayeed and Captain Anwar. I took further training in Raygonj, Panighata and Shiliguri after I was made the leader of my team. I fought in deferent places of Dinajpur District under sector 7 and carried out operations in “Boro Gram”,” New Town” and “Rudrani”.

The battle in where I was shot took place on 31st July in a village named “Bharam” in Fulbari. We were to ambush a military convoy at dawn. So we took position from the night before. But somehow our positions were betrayed and the army got air of us. They didn’t show up in the morning.  We went inside the village for food. In the mean time, with the aid of Razakars, the army had surrounded the area and caught us off guard. My fellow mate Muzaffar took the charge of covering fire while we tried to escape. Muzaffar sacrificed himself saving the whole team. I got shot in my left femur while getting back. I would have been dead if the reinforcements hadn’t arrived just in time.

Wounded, I was sent to Balurghat Hospital and then deferent Military Hospital. I was there till the historical moment of independence. I returned to Bangladesh as a free man and in 1972 I got admitted in Dhaka Medical College. I graduated from DMC in 1978 and pursued my carrier in orthopedics. As I was shot in the femur, that was somewhat an inspiration for me for taking up orthopedics as a career as well as Dr. R. J Garst, I met in early 1972 for my treatment.

I’ve also served as the health advisor of “Muktijoddha Kalyan Trust” where I have treated many of my fellow freedom fighters. The words of Dr. Ronald Joseph Garst, my mentor, will always be my motivation for the relentless service I want to render to my beloved country-“these fighters are your other family. You are one of them. Doing something for them is the next war you must fight” 


Short Overview of Prof. Dr. M Amjad Hossain


Upon completion of his graduation in Medicine in the year of 1978, Prof. Dr. M Amjad Hossain followed his professional career to orthopedics as well as successfully achieved his MS Degree from National Institue of Traumatology and Orthopaedic Rehabilitation under University of Dhaka (1986). In every sphere of his life, he has devoted his time and tried to engage and serve to the Orthopaedic department of various Institutions across the nationally and Internationally.  

With the growing development of Orthopaedic Surgery and implants devices, he has restlessly started serving on the treatment of osteoporosis particularly for the elderly population and devoted himself to make strong establishment on arthroplasty surgery in Rheumatoid, Osteporosis and Degenerative arthritis affecting and disabling patients.

 

He has achieved highly specialized foreign fellowship in the field of Joint & Hip replacement and extremely trained himself at various centres.  Prof. C.S Ranawat who is an extraordinary specialized on Orthopaedic Surgery stays in NY, USA. Prof. Ranawat also given special surgery training to Prof. Dr. M Amjad Hossain recently.

Prof. Dr. M Amjad Hossain also took part in the Liberation War of Bangladesh in 1971 (Sector 7). At that time, he served to many disabled and injured fighters who wounded by Pakistani Army. As well as he was shot on his femur. At a point, he was treated by DR. R.J. Garst and get cured. After the announcement of liberty he came back to Bangladesh freely with cured. As it was everything well that Bangladesh won the Freedom and achieved the Liberty but still from that moment Prof. Dr. M Amjad felt he will dedicate his rest of life for the people serving them who is becoming disabled by accident or any other natural disaster.
When he was in the Bed of Hospital with a severe pain of his Femur, he thought about the days ashed, he thought about the people and thought about the Orthopaedic. 

He persuade himself with lots of training on the update issues and experience exchange with the most of leading orthopedic fellows of many countries. Among them USA, Singapore, Germany, Australia and India has actively contributed a new-era of his professional excellence today.

What does Dr. M Amjad say about his success and Workplace 


Prof. Dr. M Amjad Hossain firstly thank to the #LABAID HOSPITAL LTD# situated at Dhanmondi, Dhaka, Bangladesh. He is currently #Chief Consultant# of Orthopaedic Surgery Department in LABAID HOSPITAL LTD. The answer of the question is still need to be express why does he thank to LABAID HOSPITAL. It is known to almost everyone. Although there are many many famous Hospital available in Bangladesh with International standards but it was not possible to set up an environment completely for Orthopadeic Surgeons. What it implies here an environment? 




For a highly professional Ortho Surgeon, the following things are need completely for a success on their Arthroplasty. If a Ortho surgeon get an prospective and well managed environment before going to the operating room, he/she can make success better.
  • A management Team of Implants Material 
  • An operating Theater with highly Safety & Sterile Environment
  • Nursing Staff
  • A trusted qualified vendor who always supply Implants having knowledge about "AMERICAN SOCIETY FOR TESTING AND MATERIAL (ASTM).
  • A Team for assist on operating room  
Also the following reference and knowledge should have into the team.






  • Essential requirements for non active medical devices.
  • Standard for non-active surgical implants
  • Standard for instrumentation for use in association with surgical implants
  • Standard for Joint replacement implants
  • Standard for hip joint replacement implants
  • Standard for knee joint replacement implants
  •  One step forward-two steps back: early femoral component loosening in the newer design of cemented hip replacement
  • Dynamic erosion of large implant surfaces by soft tissue in Advances in Bio materials 
  • Functional aspects of the abductor muscles of the hip
  • Forces transmitted by joints in the human body proc. Instn Mech. Engrs
  • Mechanism of fracture of the femoral prosthesis in total hip replacement Int. Orthopedic


So as I was saying, LABAID was able to provide the necessary elements with expensive implants & tools to provide Hip & Knee replacement services to the people who unexpectedly victims for it. And LABAID is committed to make this Total Hip & Knee replacement services more effective day by day following the developed countries as doing around the world and offer it to the all classes of people across the nationally and internationally. 


 Success Figures of Prof. Dr. M Amjad with LABAID


From the starting stage of Total Hip & Knee replacement in #LABAID HOSPITAL LTD# Prof. Amjad Hossain nearly Replaced over 600 Hip & Knee successfully. So, it is certainly a great achievement for a Surgeon as well as prospective credit for LABAID HOSPITAL LTD. 

As gathered info: after operation (Staring from 1st day to 1 year) the team of Orthopaedic Surgery Department always keep contact with patients and keep a storage of patient's daily, weekly, monthly, quarter yearly, half yearly & yearly report of Progress. Prof. Dr. M Amjad highly believe this all patients truck report will not only help us to best practices on Hip & Knee replacements but also it will help the next day revolutionary of Medical Science which will be benefited to the next generation and young Ortho. Professional.    

A message to the young Medical Professional by Prof. Dr. M Amjad Hossain

It is known to all that Surgery like Total Hip or Knee replacement is very tough to be success even very expensive. Dr. messages that Joint Replacement is no longer difficult to get success by a surgeon. He said it is still possible to confirm 100% success on Joint Replacement but need to follow an specialized before your start on as I did Prof. Ranawat. Prof. Dr. M Amjad trying to express it notably and advice's the young professional not to go abroad for any training or special fellow for Joint Replacement as it is worthily available in Bangladesh now. He also wish the young medical students of my countries will be able to trained them on Joint Replacement with international standard even more effectively with a very low costs and once they will be the leader of it and offer service to the population as low costs as possible. 
As the maximum people of Bangladesh are living in poverty line, so many of Patients who are seeking for joint replacement need not to feel fear. Because LABAID Hospital Ltd. always trying to offer this services as low costs as possible.